We now know that the characteristic atypical lymphocytes, carefully described morphologically by downey and mckinlay, 2. The presenting symptoms of acute im can range from the obvious, such as persistent exudative tonsillitis and marked cervical lymphadenopathy, to the more vague symptoms of fatigue and malaise. For this reason, the purpose of this work was to describe the clinical and laboratory characteristics of infection by epsteinbarr. Feb 27, 2015 infectious mononucleosis is the name coined by sprunt and evans in 1920 1 for an acute infectious disease consisting of fever, cervical lymphadenopathy and pharyngitis accompanied by atypical large peripheral blood lymphocytes. Epsteinbarr virus, mononucleosis, pediatric infections. It is also known as glandular fever, the kissing disease, and mono. There is no treatment for mono, but supportive care involves resting and drinking plenty of. Infectious mononucleosis im is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy. See page 1201 for definitions of strengthofrecommendation labels. Infectious mononucleosis mono is caused by an epsteinbarr virus ebv infection. Dec 05, 2018 epsteinbarr virus ebv, or human herpesvirus 4, is a gammaherpesvirus that infects more than 95% of the worlds population. Acute infectious mononucleosis im is a common illness that presents to urgent care facilities.
Infectious mononucleosis is a common, usually mild illness. Infectious mononucleosis 4 to 7 week incubation acute selflimiting infection of the re system enlarged lymph nodes in the neck. Whereas most ebv infections of infants and children are asymptomatic or have nonspecific symptoms, infections of adolescents and. From the department of pediatrics and program in molecular medicine k. It is common among teenagers and young adults, especially college students. Infectious mononucleosis was recognized as a unique disease in the 1880s by nil filatov, a russian pediatrician, who called the syndrome. There are usually no complications, although it may take several weeks for. Infectious mononucleosis jama pediatrics jama network. Some data derived in the united kingdom suggest that infectious mononucleosis im cases may be occurring later in life with increasing severity, requiring hospitalization. Brenner childrens pediatric emergency department has been temporarily relocated to a newly renovated area of the adult emergency department. Infectious mononucleosis is the name coined by sprunt and evans in 1920 1 for an acute infectious disease consisting of fever, cervical lymphadenopathy and pharyngitis accompanied by atypical large peripheral blood lymphocytes.
It is most commonly caused by the epsteinbarr virus ebv. High wbc, over 20% atypical reactive lymphocytes also known as. Longo dl, fauci as, kasper dl, hauser sl, jameson jl, loscalzo j, editores. Mononucleosis infecciosa by ricardo vicentino issuu.
Jun 21, 2015 infectious mononucleosis 4 to 7 week incubation acute selflimiting infection of the re system enlarged lymph nodes in the neck. Infectious mononucleosis allergy and clinical immunology. Epsteinbarr virus ebv, or human herpesvirus 4, is a gammaherpesvirus that infects more than 95% of the worlds population. It has been reported that about 90% of the cases is caused by ebv.
She appears very tired and has a temperature of 39c. Clinical and laboratory characteristics of infectious mononucleosis by epsteinbarr virus in mexican children. Large studies of infectious mononucleosis are now decades old, but traditionally, the peak incidence of infection has been described in the 15 to 24year age range. A handout on infectious mononucleosis, written by the author of this article, is provided on page 1289. It is caused most often by the epsteinbarr virus ebv, which is in the herpesvirus family of organisms. It was initially described as drusenfieber or glandular fever in 1889, but the term infectious mononucleosis was later used in 1920 to describe six college students with a febrile illness characterized by absolute lymphocytosis and atypical. Clinical and laboratory characteristics of infectious mononucleosis. Pediatric epstein barr virus carriers with or without tonsillar enlargement.
Infectious mononucleosis is sometimes called mono or the kissing disease. Feb, 2015 mononucleosis infecciosa enfermedad del beso duration. Pablo lara vega summary infectious mononucleosis im is a clinical syndrome caused by epsteinbarr virus ebv. Jul 27, 2016 infectious mononucleosis is a common infection caused by the epsteinbarr virus ebv. At least one out of four teenagers and young adults who get infected with ebv will develop infectious mononucleosis. In latin american countries, there are little information pertaining to the clinical manifestations and complications of this disease.
Most americans have had an ebv infection by age 40 years. Infectious mononucleosis im, mono, also known as glandular fever, is an infection usually caused by the epsteinbarr virus ebv. Mononucleosis infecciosa enfermedades infecciosas manual. The familiar nickname for mononucleosis or mono, the kissing disease, is somewhat misleading. We now know that the characteristic atypical lymphocytes, carefully described. Pediatric mononucleosis and epsteinbarr virus infection. Pdf clinical and laboratory characteristics of infectious. Most people become infected with ebv at some point in their lives.
They described the clinical characteristics of epsteinbarr virus ebv infectious mononucleosis. Pablo lara vega summary infectious mononucleosis im is a clinical syndrome. Jul 20, 2012 infectious mononucleosis im or mononucleosis syndrome is caused by an acute infection of epsteinbarr virus ebv. Diagnosis of atypical cases of infectious mononucleosis. Sore throat, fever, rash malaise, lethargy, extreme tiredness liver and spleen involvement and enlargement hematology. Epsteinbarr virus ebv infectious mononucleosis mono. Infectious mononucleosis im is a common childhoodadolescent illness.
Infectious mononucleosis im or mononucleosis syndrome is caused by an acute infection of epsteinbarr virus. The virus is spread by intimate oral contact among teenagers and young adults. Clinical and laboratory characteristics of infectious. Since ebv is spread by saliva, close contact, such as kissing or young children playing together, spreads the disease. Infectious mononucleosis disease fact sheet spanish. Clinical and laboratory characteristics of infectious mononucleosis by. The most common manifestation of primary infection with this organism is acute infectious mononucleosis, a selflimited clinical syndrome that most frequently affects adolescents and young adults. It can be caused by a number of pathogens, but this chapter only discusses infectious mononucleosis due to primary epsteinbarr virus ebv infection. Symptoms vary but may include swollen lymph glands, sore throat, and tiredness. Epsteinbarr virus is a member of the herpesvirus family and is one of the most common viruses that infects humans. Clinical and laboratory characteristics of infectious mononucleosis by epsteinbarr virus in mexican children article pdf available in bmc research notes 51. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Symptoms of infectious mononucleosis include fatigue, sore throat, fever, and swollen lymph nodes. Pdf infectious mononucleosis im or mononucleosis syndrome is caused by an acute infection of epsteinbarr virus.
It was initially described as drusenfieber or gl it seems to us that you have your javascript disabled on your browser. Pdf this journal feature begins with a case vignette highlighting a common clinical. Like all herpesviruses, ebv stays within the body once a person is infected. Vyas, md, phd, assistant professor in medicine, harvard medical school. All cases diagnosed as infectious mononucleosis secondary to epsteinbarr virus with a compatible clinical manifestation and serological confirmation in children attended at national institute of pediatrics nip, mexico city from 6th november, 1970 to 30th july, 2011 were included in the study. Most people are infected by the virus as children, when the disease produces few or no symptoms. Our patient was only 2 years old but had heterophil. Epsteinbarr virus ebv is the most common cause of infectious mononucleosis, but other viruses can also cause this disease. Epsteinbarr virus infections, coinfection, infectious mononucleosis, pediatrics. The association between infectious mononucleosis and ebv was described in the late 1960s. Infectious mononucleosis is an acute, selflimited, benign illness that occurs in children and young adults after primary infection with epsteinbarr virus ebv, cytomegalovirus cmv, and other infectious agents. In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and tiredness.
Jul 01, 2001 during a 3year period, we diagnosed 17 cases of atypical infectious mononucleosis and 11 cases of typical infectious mononucleosis through the screening of peripheral blood samples for the presence of atypical and apoptotic lymphocytes. Classic physical findings include fever, splenomegaly, pharyngitis, and lymphadenopathy. Sep 20, 2018 infectious mononucleosis was first described by sprunt and evans in the bulletin of the johns hopkins hospital in 1920. It is most often caused by infection with the epsteinbarr virus ebv. Mononucleosis infectious mononucleosis n siena pediatrics. The incidence of ebvassociated infectious mononucleosis in the united states has been estimated to be 1.
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